--- description: WWE Wrestlepalooza odds, AI predictions, and expert picks for Cena vs. Lesnar, AJ Lee’s return, and more action from Indianapolis. title: WWE Wrestlepalooza Odds 2025: John Cena, AJ Lee, AI Predictions image: https://cdn.oddspedia.com/images/betting/2025/09/USATSI_18017276.jpg --- Six appearances. That’s it. After that? We’ll have seen the last of John Cena the in-ring performer. This is the crescendo on a G.O.A.T level career. This Saturday he’ll head to WWE Wrestlepalooza at Gainbridge Fieldhouse in Indianapolis to face off with one of his oldest nemeses in the Beast Incarnate, Brock Lesnar. > "...having the biggest title in the Fed on an absent champion doesn’t feel great. For that reason: Drew McIntyre is great value" What else does the first PLE on ESPN hold? What about AJ Lee’s first WWE match in a decade? The Usos back in action together for the first time tagging as a team since Money in the Bank 2023? This one should be a doozy – and we’ve got the [WWE Wrestlepalooza odds](https://oddspedia.com/tv/world-tv/wwe-wrestlepalooza) and analysis to get you ready for a big night in Indy. ## WWE Wrestlepalooza odds | Match | Favorite | Underdog | | ------------------------------ | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ | | Cena vs. Lesnar | ![John Cena](https://cdn.oddspedia.com/images/betting/4/2025/02/USATSI_16422380.png)John Cena (-303) | ![Brock Lesnar](https://cdn.oddspedia.com/images/betting/2025/09/USATSI_18017276.png)Brock Lesnar (+225) | | WWE Championship | ![Cody Rhodes](https://cdn.oddspedia.com/images/betting/4/2024/04/USATSI_23734025_168398502_lowres.png)Cody Rhodes (c) (-1250) | ![Drew McIntyre](https://cdn.oddspedia.com/images/betting/4/2025/02/DM.png)Drew McIntyre (+600) | | WWE Women’s World Championship | ![Stephanie Vacquer](https://cdn.oddspedia.com/images/betting/2025/09/Stephanie-Vaquer.png)Stephanie Vaquer (-250) | ![Iyo Sky](https://cdn.oddspedia.com/images/betting/4/2025/04/IYOSKY.png)Iyo Sky (+175) | | Mixed Tag Match | **![CM Punk](https://cdn.oddspedia.com/images/betting/4/2025/02/USATSI_22392579-1.png)![AJ Lee](https://cdn.oddspedia.com/images/betting/2025/09/AJ-Lee.png)**CM Punk & AJ Lee (-2000) | ![Seth Rollins](https://cdn.oddspedia.com/images/betting/4/2025/02/SR.png)![Becky Lynch](https://cdn.oddspedia.com/images/betting/4/2025/05/BeckyLynchIcon.png)Seth Rollins & Becky Lynch (+800) | | Tag Team Match | ![Bron Breakker](https://cdn.oddspedia.com/images/betting/4/2025/04/BronBreakker.png)![Bronson Reed](https://cdn.oddspedia.com/images/betting/4/2025/07/BronsonReed.png)The Vision (-303) | **![Jey Uso](https://cdn.oddspedia.com/images/betting/4/2024/04/USATSI_25321822_168398502_lowres.png)**The Usos (+225) | Odds accurate as of September 19 ## WWE Wrestlepalooza odds analysis ### John Cena vs. Brock Lesnar Normally we wouldn’t analyze a match without a sportsbook setting a market… but there’s no surprises at all in this one. Lesnar is going to look strong, as always, and Big John is going to be thrown around like a ragdoll, but then he’ll power up and power out and take the W for what may be his third or fourth from last match. **🔥 Wild Wrestlepalooza Hot Take** – Seth Rollins interferes in some way, rolling Brock Lesnar and John Cena into the Wargames match at Survivor Series and the biggest match in WWE history follows. ### WWE Championship – Cody Rhodes vs. Drew McIntyre Cody Rhodes is a busy man. He won the WWE Championship back from John Cena at [WWE SummerSlam](https://oddspedia.com/insights/features/wwe-summerslam-odds) and subsequently went off TV with a kayfabe injury caused by his WWE Wrestlepalooza opponent, Drew McIntyre. In the interim he was actually filming the Streetfighter movie and welcoming his second child into the world. Now he’s back, but it feels temporary: having the biggest title in the Fed on an absent champion doesn’t feel great. For that reason: Drew McIntyre is great value at +600. **🔥 Wild Wrestlepalooza Hot Take** – Randy Orton interferes, turning on Cody Rhodes, setting up a feud that will run and run through to WrestleMania in 2026. ### WWE Women’s World Championship – IYO SKY vs. Stephanie Vaquer Stephanie Vacquer rides a meteoric push since she stepped up to the main roster earlier in 2025, and is a worthy favorite in this market. A solid worker, aura for days, international appeal… …but Iyo SKY may be the best wrestler in the world right now. And she is incredibly over with the crowd. _Is anyone else’s wife tuning into WWE Raw just to watch the #RhIyo segments?_ I would love either of these two to win it clean, but a Face vs. Face title match needs moral conflict, and I think we’ll see the Kabuki Warriors heel turn cost their former Damage Control compatriot the title, or bring out Rhea Ripley who inadvertently costs her friend the belt. **🔥 Wild Wrestlepalooza Hot Take** – this match has a clean finish with Sky putting over Vacquer (yes, that would a surprise) ### Mixed Tag Match – CM Punk and AJ Lee vs. Seth Rollins and Becky Lynch The feel-good reunion story of the holiday season come early. It’s husband and wife vs. husband and wife as CM Punk made a call and brought back his wife and three-time WWE Divas Champion, AJ Lee. This marks the first time Lee has entered a WWE ring, or any other ring, in anger since 2015\. She didn’t however, stop training. AJ Lee looks in great condition and ready for a match with three of the best wrestlers in the world right now. Will she have ring rust? Will she be nervous? Will it matter? We can expect this to be the bloody nose Punk has been trying to give Seth since [Elimination Chamber](https://oddspedia.com/insights/features/wwe-elimination-chamber-odds) in February. **🔥 Wild Wrestlepalooza Hot Take** – AJ Lee flips the script and turns on her man. ### The Usos vs. Bronson Reed & Bron Breakker The Usos are back on the same team, but are the seeds being sown on a Jey Uso heel turn? Some of Main Event Jey Uso’s actions have been less than pure of heart over the last couple of weeks. Is there a chance the creative team are pivoting him into a heel role so he and Jimmy can run it back again at [Wrestlemania](https://oddspedia.com/insights/features/wwe-wrestlemania-odds) in 2026? Regardless of the long term plan: Survivor Series and the now-annual Wargames matches are looming on the horizon: it’s about time to start picking sides and we can already see the The Vision vs. The Bloodline as the mens headliner. **🔥 Wild Wrestlepalooza Hot Take** – Roman Reigns interferes during or after the match to setup Wargames. ## WWE Wrestlepalooza expert and AI predictions | | 👨‍🎓 Expert Pick | 🤖 AI Prediction | | ------------------------------ | ----------------- | ------------------------- | | Cena vs. Lesnar | John Cena | Brock Lesnar (68.8%) | | WWE Championship | Drew McIntyre | Cody Rhodes (88.3%) | | WWE Women’s World Championship | Stephanie Vacquer | Stephanie Vacquer (59.1%) | | Mixed Tag Match | CM Punk & AJ Lee | CM Punk & AJ Lee (78.3%) | | Tag Team Match | The Vision | The Vision (85.5%) | ### How our AI Predictions are made Oddspedia Insights WWE Wrestlepalooza Predictions are created using a proprietary analytical model designed for sports entertainment. The process begins by assigning weighted probabilities to four core pillars: current wrestler momentum, storyline cohesion, future booking potential, and external factors. This weighted data then fuels a simulation of the match run 1,000 times to determine the most probable outcome. This system moves beyond simple statistics, generating a data-driven forecast grounded in the unique narrative and performance logic of professional wrestling, resulting in a highly nuanced and authoritative prediction. ## Read our past WWE predictions * [WrestleMania Odds and Predictions](https://oddspedia.com/insights/features/wwe-wrestlemania-odds) * [Royal Rumble Odds and Predictions](https://oddspedia.com/insights/features/wwe-royal-rumble-odds) * [Elimination Chamber Odds and Predictions](https://oddspedia.com/insights/features/wwe-elimination-chamber-odds) * [WWE Backlash Odds and Predictions](https://oddspedia.com/insights/features/wwe-backlash-odds) * [WWE Money in the Bank Odds and Predictions](https://oddspedia.com/insights/features/wwe-money-in-the-bank-odds) * [WWE SummerSlam Odds and Predictions](https://oddspedia.com/insights/features/wwe-summerslam-odds) * [WWE Clash in Paris Odds and Predictions](https://oddspedia.com/insights/features/wwe-clash-in-paris-odds) ## WWE Wrestlepalooza card * John Cena vs. Brock Lesnar * **WWE Championship** – Cody Rhodes (c) vs. Drew McIntyre * **WWE Women’s World Championship** – Stephanie Vacquer vs. Iyo SKY * **Mixed Tag Match** – AJ Lee & CM Punk vs. Seth Rollins & Becky Lynch * **Tag Team Match** – The Usos vs. The Vision ## WWE Wrestlepalooza info | What? | WWE Wrestlepalooza | | ------------- | ----------------------------------------- | | When? | Saturday September 20 | | Where? | Gainbridge Fieldhouse in Indianapolis, IN | | How to watch? | US: ESPN / UK and ROW: Netflix | ## Live WWE Wrestlepalooza odds [](https://oddspedia.com) [](https://oddspedia.com) [](https://oddspedia.com) [](https://oddspedia.com) [](https://oddspedia.com) Related Tags: * [#Novelty Bets ](/insights/tags/novelty-bets) * [#Special Bets ](/insights/tags/special-bets) * [#Wrestling ](/insights/tags/wrestling) Don't forget to share with friends * [![Facebook Icon](/placeholder.svg)](https://www.facebook.com/oddspediaglobal) * [![X Icon](/placeholder.svg)](https://x.com/oddspedia) * [![Instagram Icon](/placeholder.svg)](https://www.instagram.com/oddspediaglobal) * [![Telegram Icon](/placeholder.svg)](https://t.me/oddspedia) ![Andy Whiteoak](/placeholder.svg) Andy Whiteoak ![Andy Whiteoak](/placeholder.svg) Senior Sports Editor Andy is a sports writer and content creator specializing in performance data and analytics. He is also one of the UK’s top football coaches, leading a top-5 ranked team. He regularly appears in local and national media covering the UK’s fastest-growing sport. Though football is his primary passion, Andy has experience in college basketball, pro basketball, and MLB. With a degree in Film and Media, he has a rich background in digital communication and marketing. Andy excels at creating intelligent, data-driven content that entertains and informs bettors, with his work quoted in Sports Illustrated and Newsweek. His analytical approach to betting mirrors his content creation, ensuring well-supported perspectives and predictions. 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You can manage your preferences and find out more by clicking the ‘Customise’ button below. Customise Accept All ) ( ( ( ( ( ( ( /( )\ ) )\ ) )\ ) )\ ) )\ ) )\ ) ( )\()) (()/( (()/( (()/( (()/( ( (()/( (()/( )\ ((_)\ /(_)) /(_)) /(_)) /(_)) )\ /(_)) /(_)) ((((_)( ((_) (_))_ (_))_ (_)) (_)) ((_) (_))_ (_)) )\ _ )\ / _ \ | \ | \ / __| | _ \ | __| | \ |_ _| (_)_\(_) | (_) | | |) | | |) | \__ \ | _/ | _| | |) | | | / _ \ \___/ |___/ |___/ |___/ |_| |___| |___/ |___| /_/ \_\ ```json {"@context":"http://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https://oddspedia.com/insights","name":"Insights"}},{"@type":"ListItem","position":2,"item":{"@id":"https://oddspedia.com/insights/features","name":"Oddspedia Features"}},{"@type":"ListItem","position":3,"item":{"@id":"https://oddspedia.com/insights/features/wwe-wrestlepalooza-odds","name":"WWE Wrestlepalooza Odds 2025: Returns, Reunions, Revenge!"}}]} {"@context":"http://schema.org","@type":"NewsArticle","url":"https://oddspedia.com/insights/features/wwe-wrestlepalooza-odds","dateCreated":"2025-09-19T18:40:09+00:00","datePublished":"2025-09-19T18:40:09+00:00","dateModified":"2026-09-10T10:13:51+00:00","articleSection":"Oddspedia Features","mainEntityOfPage":{"@type":"WebPage","name":"WWE Wrestlepalooza Odds 2025: Returns, Reunions, Revenge!","@id":"https://oddspedia.com/insights/features/wwe-wrestlepalooza-odds"},"headline":"WWE Wrestlepalooza Odds 2025: Returns, Reunions, Revenge!","description":"WWE Wrestlepalooza odds, AI predictions, and expert picks for Cena vs. Lesnar, AJ Lee’s return, and more action from Indianapolis.","image":[{"@type":"ImageObject","url":"https://cdn.oddspedia.com/images/betting/2025/09/USATSI_18017276.jpg","width":1000,"height":565}],"author":{"@context":"http://schema.org","@type":"Person","name":"Andy Whiteoak","gender":"Male","url":"https://oddspedia.com/experts/andy-whiteoak","jobTitle":"Senior Sports Editor","image":"https://cdn.oddspedia.com/images/betting/2025/01/Andy-pic-1.jpg","affiliation":{"@type":"Organization","name":"Oddspedia"},"description":"<p>Andy is a sports writer and content creator specializing in performance data and analytics. He is also one of the UK&#8217;s top football coaches, leading a top-5 ranked team. He regularly appears in local and national media covering the UK&#8217;s fastest-growing sport. Though football is his primary passion, Andy has experience in college basketball, pro basketball, and MLB. With a degree in Film and Media, he has a rich background in digital communication and marketing. Andy excels at creating intelligent, data-driven content that entertains and informs bettors, with his work quoted in Sports Illustrated and Newsweek. His analytical approach to betting mirrors his content creation, ensuring well-supported perspectives and predictions.</p>\n","memberOf":[{"@type":"Organization","name":"Oddspedia","brand":"Oddspedia","sameAs":["https://x.com/oddspedia","https://www.linkedin.com/company/oddspedia","https://www.facebook.com/oddspediaglobal","https://www.instagram.com/oddspediaglobal","https://www.youtube.com/oddspedia/videos","https://t.me/oddspedia","https://discord.gg/Thp44bSCxN"]}],"sameAs":[]},"publisher":{"@type":"Organization","name":"Oddspedia","sameAs":["https://oddspedia.com","https://www.facebook.com/oddspediaglobal","https://www.instagram.com/oddspediaglobal","https://x.com/oddspedia","https://www.youtube.com/oddspedia/videos"],"logo":{"@type":"ImageObject","url":"https://cdn.oddspedia.com/images/static/brand-logos/logo-light.svg","width":164,"height":18}},"inLanguage":"en"} ```