NFL Week 4 Odds, Spreads and Moneylines: Chiefs-Chargers Headline Rivalry Weekend

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  • Vikings vs Packers, Cowboys vs Giants amongst a raft of divisional action in Week 4
  • Can Anthony Richardson prove he’s a legit NFL starter? Or is he a permanent injury risk?
  • Lions host Seahawks in MNF showdown as the main event of Week 4

The fourth week of football marks the conclusion of the first month of the new campaign, and NFL Week 4 odds will soon tell the tale of how oddsmakers view the season up to this point.

Although NFL Week 4 odds are not available just yet, they will be as soon as the previous week’s matchups conclude.

Here, we will analyze every matchup from around the league and provide insight as to the strengths and weaknesses of every team, potential opportunities for prop markets, and which teams we are willing to back at the best sportsbooks.

NFL Week 4 odds

Matchup Time (ET) Moneyline Spread Total
Cowboys at Giants Thursday, 8:15 p.m. tbc tbc tbc
Saints at Falcons Sunday, 1:00pm tbc tbc tbc
Rams at Bears Sunday, 1:00 p.m. tbc tbc tbc
Vikings at Packers Sunday, 1:00 p.m. tbc tbc tbc
Steelers at Colts Sunday, 1:00 p.m. tbc tbc tbc
Broncos at Jets Sunday, 1:00 p.m. tbc tbc tbc
Eagles at Buccaneers Sunday, 1:00 p.m. tbc tbc tbc
Bengals at Panthers Sunday, 1:00 p.m. tbc tbc tbc
Jaguars at Texans Sunday, 1:00 p.m. tbc tbc tbc
Commanders at Cardinals Sunday, 4:05 p.m. tbc tbc tbc
Patriots at 49ers Sunday, 4:05 p.m. tbc tbc tbc
Browns at Raiders Sunday, 4:25 p.m. tbc tbc tbc
Chiefs at Chargers Sunday, 4:25 p.m. tbc tbc tbc
Bills at Ravens Sunday, 8:20 p.m. tbc tbc tbc
Titans at Dolphins Monday, 7:30 p.m. tbc tbc tbc
Seahawks at Lions Monday, 8:15 p.m. tbc tbc tbc

Odds will be added as soon as markets go live with the best sportsbooks

NFL Week 4 opening odds

NFL Week 4 odds will be released on Sunday following the conclusion of the Week 3 games and will be updated here as soon as they are available.

NFL Week 4 betting lines

Dallas Cowboys @ New York Giants

No team has won the NFC East in back-to-back seasons since the Eagles in 2003-04, which means that history is working against the Cowboys. However, they’ve been nothing short of dominant against the Giants in recent years and are still aiming to accomplish their elusive goal of winning a Super Bowl.

New Orleans Saints @ Atlanta Falcons

A classic NFC South matchup between two familiar faces, both the Saints and Falcons invested at quarterback and have selling points all over the roster. Expectations are higher for the Falcons, even despite them using the eighth pick in the draft to select backup QB Michael Penix Jr.

Los Angele Rams @ Chicago Bears

The Rams should be a real litmus test for Caleb Williams, one of the most hyped prospects of the past decade. Their offense can be one of the most prolific in the league at its very best, while the defense got better during the offseason even with Aaron Donald retiring.

Minnesota Vikings @ Green Bay Packers

The first matchup between J.J. McCarthy and Jordan Love could be a snapshot of the future of many rivalry matchups in the NFC North. The Vikings have immense talent at the skill positions, while Love and a young Green Bay offense have shown lots of promise thus far,

Pittsburgh Steelers @ Indianapolis Colts

The days of Ben Roethlisberger and Peyton Manning are gone, and both teams are searching for answers at the quarterback position. The Colts believe they have their guy in second-year Anthony Richardson and put weapons around him, while the Steelers have their choice of either Russell Wilson or Justin Fields as they prepare to take advantage of a thin Colts secondary.

Denver Broncos @ New York Jets

Sean Payton sparked a rivalry with the Jets a year ago after he called out their offensive coordinator and ex-Denver head coach Nathaniel Hackett. It’s hard to find a bigger gap in experience than 40-year-old Aaron Rodgers and rookie Bo Nix, which sets the stage for an intriguing matchup.

Philadelphia Eagles @ Tampa Bay Buccaneers

The Eagles could not stop Baker Mayfield and the Bucs’ passing attack when they met in the playoffs a year ago and will be looking for their revenge. Saquon Barkley’s arrival adds another dimension to the Philly offense, while they looked to get younger on defense during the summer.

Cincinnati Bengals @ Carolina Panthers

Joe Burrow is back from the second season-ending injury of his career and is ready to take on 2023 first-overall pick Bryce Young. While Burrow turned around an unfavorable situation almost instantaneously, Young has not been able to do the same and is playing with an inferior roster.

Jacksonville Jaguars @ Houston Texans

The Jags were 8-3 a year ago when Trevor Lawrence suffered an ankle injury, allowing the Texans to make a late comeback and win the division title. They’ll be looking for revenge, but it won’t come easy against a team that opened up its checkbook to big-name free agents during the offseason and is a public darling in NFL Week 4 odds.

Washington Commanders @ Arizona Cardinals

Neither one of the Commanders or the Cardinals found themselves in the best of times recently. This matchup pits second-overall pick Jayden Daniels against fourth pick Marvin Harrison Jr., but with a twist—Commanders’ offensive coordinator Kliff Kingsbury coached the Cardinals and could still have some insight on their strengths and weaknesses, particularly at quarterback.

New England Patriots @ San Francisco 49ers

The Patriots are in a hard reset following the departure of Bill Belichick and since they still haven’t recovered from the loss of Tom Brady. The Niners, meanwhile, are in championship-or-bust mode and have the most complete roster in the league top-to-bottom. This could easily go under the NFL Week 4 over/under line because of the strength of the Niners’ defense.

Cleveland Browns @ Las Vegas Raiders

Quarterback play is key for both of these teams. Deshaun Watson is one of the highest-paid players in the league but has not performed like anything better than a bottom-five player at his position, while the Raiders missed an opportunity to draft their next franchise player and have to survive with Aidan O’Connell and Gardner Minshew.

Kansas City Chiefs @ Los Angeles Chargers

Jim Harbaugh’s first chance to take down Patrick Mahomes and the Chiefs will tell a lot about his approach and where his team is at. The Bolts are likely to be a more ground-based team than in years past, but they’ll have to get past a Chiefs defense that was second in points, yards, and sacks last year.

Buffalo Bills @ Baltimore Ravens

A couple of second-tier AFC contenders, per NFL futures betting odds, the Bills and Ravens are fighting for playoff position every time they take the field. Both teams resemble one another in the sense that their quarterbacks are always threats to make plays with their arms or legs, and the question is which defense will be up for the challenge.

Tennessee Titans @ Miami Dolphins

The Dolphins can put up numbers in their stadium in fair weather, that much is known. The Titans are trying to find themselves as a franchise but made a number of improvements to their personnel on both sides and had an elite run defense a year ago.

Seattle Seahawks @ Detroit Lions

The Seahawks’ appointment of coach Mike MacDonald was a sign they want to continue to build their teams with a defensive focus. That’s convenient in this matchup since the Lions have one of the highest-scoring offenses in the league over the past few years, making this a strength-on-strength showdown.

NFL Week 4 picks and predictions

The Ravens are a more complete team than the Bills and have the bonus of playing at home. It’s still early in the year, and teams are going to need more time to figure out how to slow down the combination of Jackson and Derrick Henry. Watch for the Ravens to take this one.

Although we’re not sold on the Jets and a 40-year-old, post-Achilles-op quarterback, we equally don’t believe in Nix and the Broncos. The rookie QB’s long college tenure means that he’s likely to be overwhelmed like some of his classmates, but he also has a much lower ceiling and the worst of the two defenses supporting him.

The Eagles are a prideful team that went through an uncharacteristic slump last year. Jalen Hurts will know that the best way to motivate his team is to take down the same Buccaneers that kicked them out of the playoffs, and we expect them to do just that.

Tennessee improved its roster during the offseason but is still at a large talent disparity compared to Miami. L’Jarius Sneed and the Chiefs’ defense did a nice job when they matched up with Tyreek Hill a year ago, but he should find it much different in a new location.

Our best NFL betting sites

To make sure you get the most value on your NFL odds, go to the best NFL betting sites prior to placing your wagers throughout the season.

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