NFL Week 6 Odds, Spreads and Moneylines: Caleb Williams in London

© David Banks-USA TODAY Sports
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  • Jaguars and Bears face off in London
  • Jayden Daniels faces Lamar Jackson – his pro-game prototype
  • How will Mike MacDonald’s Seahawks fare against the in-division 49ers?

NFL Week 6 odds provide yet another opportunity for NFL bettors to share their thoughts on 14 matchups across the league in the clearest way possible: at the sportsbooks.

The week starts with an NFC West showdown between the San Francisco 49ers and Seattle Seahawks and finishes with an AFC East matchup between the Buffalo Bills and New York Jets.

The Jacksonville Jaguars and Chicago Bears will also make the journey across the pond to play in Tottenham Hotspur Stadium in London, England, to kickstart the Sunday schedule.

Here, we will break down those games and all of those others in NFL Week 6, betting odds, and our favorite picks.

NFL Week 6 odds

Matchup Time (ET) Moneyline Spread O/U
49ers at Seahawks Thurs 8:15 p.m. tbc tbc tbc
Jaguars at Bears Sun 9:30 a.m. -115/ -105 Bears -2.5 46.5
Cardinals at Packers Sun 1:00 p.m. tbc tbc tbc
Colts at Titans Sun 1:00 p.m. tbc tbc tbc
Texans at Patriots Sun 1:00 p.m. tbc tbc tbc
Buccaneers at Saints Sun 1:00 p.m. tbc tbc tbc
Browns at Eagles Sun 1:00 p.m. tbc tbc tbc
Commanders at Ravens Sun 1:00 p.m. tbc tbc tbc
Chargers at Broncos Sun 4:05 p.m. tbc tbc tbc
Steelers at Raiders Sun 4:05 p.m. tbc tbc tbc
Lions at Cowboys Sun 4:25 p.m. tbc tbc tbc
Falcons at Panthers Sun 4:25 p.m. tbc tbc tbc
Bengals at Giants Sun 8:20 p.m. tbc tbc tbc
Bills at Jets Mon 8:15 p.m. tbc tbc tbc

NFL Week 6 opening odds

NFL Week 6 odds will be released on Sunday night of the previous week as teams around the league finish their games. Those NFL Week 6 betting spreads, moneylines, and over/unders will be updated here as soon as they are available.

NFL Week 6 betting lines

49ers at Seahawks

The Niners dominated the NFC West in recent years and made no exception for the Seahawks, beating them in both matchups each of the last two years. Seattle enters the matchup with a new defensive focus thanks to head coach Mike MacDonald but has years of inferiority to overcome.

Jaguars at Bears

The Jags have a second home in London and went 2-0 there a year ago. Meanwhile, Bears’ rookie QB Caleb Williams will be in for a tough assignment winning in another continent with a team he only recently joined.

Cardinals at Packers

Kyler Murray was a former first-overall pick, but Jordan Love is the young QB who garnered more belief from supporters around the league. The strong-armed Love could have a fun time against a porous Cardinals secondary, especially as the weather starts to get colder.

Colts at Titans

The Colts showed tremendous promise a year ago and finished with a winning record, but there are still concerns over the health of their players. The Titans did a nice job of putting pieces around Will Levis, but very few of them are true game-changers at this stage in their careers.

Texans at Patriots

Houston is a popular dark horse pick to win the AFC and should be able to blowout the Patriots, who are in a transitional year in every sense. A rookie QB/head coach combination combined with an offense bereft of talent is a tough formula to overcome, especially following the loss of Bill Belichick.

Buccaneers at Saints

The Bucs and Saints are fighting for an NFC South title and playoff berth, even if the Falcons are the division favorites. They split their series a year ago 1-1, but the Bucs have the better offense and were equal to the Saints on defense.

Browns at Eagles

Both teams mirror one another in the sense they play tough-nosed football, run the ball, control the clock, get after the passer, and want to have their quarterback make plays with their arm and legs. The winner will be the team that plays within the margins better, particularly at quarterback.

Commanders at Ravens

Rookie QB Jayden Daniels was likened to Lamar Jackson during the build-up to the NFL Draft and will have the chance to face him for the first time in his career. Jackson is coming off an MVP year but might have to dig into his bag of tricks to throw the ball down the field because of Washington’s stout defensive front.

Chargers at Broncos

Jim Harbaugh and Sean Payton are both highly respected coaches and will face off as division foes for the first time. Watch for LA to bring the heat against a rookie QB and for Denver to do what it can to control the clock against a master of the time of possession (Harbaugh).

Steelers at Raiders

The Raiders are almost like a lesser version of the Steelers of a year ago. They make plays on defense and give their full effort on every snap but are playing from behind at quarterback and don’t have a game-changing running back. Pittsburgh also has the luxury of going to either Russell Wilson or Justin Fields depending on the situation.

Lions at Cowboys

The Cowboys beat the Lions in a controversial ending last year and get to face them in their building again. Detroit strengthened its roster during the offseason whereas Dallas got worse with the departure of several players, which bodes well for the visitors.

Falcons at Panthers

Carolina is going to need weeks—no, months of solid football to erase the memory of a disappointing 2023 campaign. Atlanta, on the other hand, has a great roster in place and should be a top contender in the NFC if Kirk Cousins proves to be the same player he was pre-Achilles injury.

Bengals at Giants

Only once every four years do these teams match up with one another. The Bengals have a clear advantage in talent but could run into trouble if they can’t block the Giants’ defensive line that features Brian Burns, Dexter Lawrence, and Kayvon Thibodeaux.

NFL Week 6 picks and predictions

The Bears have an outstanding roster, and Trevor Lawrence needs to take the leap many expected him to a year ago. That said, asking a rookie QB in Williams to travel to Europe and win a football game feels like a stretch, and taking the Jags outright could be a strong play.

The Buccaneers won the division in their rebuilding year in 2023 and are going to steadily get better. The Saints, on the other hand, are going backward and getting older without much planning for the future.

If there’s one area of coaching that Dan Campbell excels at, it’s coaching. He will have the Lions fired up to go back to AT&T Stadium where they were “robbed” a year ago and should have them walk out with a win.

The Chargers are going to need a few years to fully take on the image of their coach, Harbaugh, but they should have no problems with the Broncos. Payton did a solid job after the first month of last year but is at a massive disadvantage with his offensive personnel.

Our best NFL betting sites

To make sure you get the most value on your NFL odds, go to the best NFL betting sites prior to placing your wagers throughout the season.

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