NFL Pick’Em Week 2 gives football fans another opportunity to put their knowledge to the test as the 2026 regular season continues. Whether you’re competing in a workplace pool, playing with friends, or simply making your own selections, picking every matchup can be a challenge.
Our NFL picks break down the Week 2 slate and highlight the teams we expect to come out on top. These selections are designed to provide a starting point for anyone looking for NFL Pick’Em Week 2 guidance before making their choices. Along with our selections, we’ll examine several intriguing matchups and explain the reasoning behind our picks. Use this guide for NFL Pick’Em Week 2 preparation.
NFL Week 2 Pick’Em Selections
Making all of your selections before kickoff can be difficult, particularly when several games appear evenly matched. Our NFL Pick’Em Week 2 selections provide a straightforward starting point for pools and contests.
Download or print our free printable NFL Week 2 pick’em sheet and make your choices before the games begin.
| Away Team |
Home Team |
Winner |
| Detroit Lions |
Buffalo Bills |
Bills |
| Carolina Panthers |
Atlanta Falcons |
Panthers |
| New Orleans Saints |
Baltimore Ravens |
Ravens |
| Minnesota Vikings |
Chicago Bears |
Bears |
| Cincinnati Bengals |
Houston Texans |
Bengals |
| Pittsburgh Steelers |
New England Patriots |
Steelers |
| Green Bay Packers |
New York Jets |
Jets |
| Cleveland Browns |
Tampa Bay Buccaneers |
Buccaneers |
| Philadelphia Eagles |
Tennessee Titans |
Titans |
| Jacksonville Jaguars |
Denver Broncos |
Jaguars |
| Las Vegas Raiders |
Los Angeles Chargers |
Chargers |
| Seattle Seahawks |
Arizona Cardinals |
Seahawks |
| Washington Commanders |
Dallas Cowboys |
Cowboys |
| Miami Dolphins |
San Francisco 49ers |
49ers |
| Indianapolis Colts |
Kansas City Chiefs |
Chiefs |
| New York Giants |
Los Angeles Rams |
Rams |
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NFL Pick’Em Week 2 Insights
Several Week 2 matchups stand out as particularly interesting when making NFL Pick’Em Week 2 selections. While some games feature clear favorites, others could come down to a handful of key plays. Here are three matchups worth paying especially close attention to when making your NFL pick’em predictions.
Minnesota Vikings vs 
Chicago Bears
The Bears are a strong Week 2 pick’em selection against the Panthers, particularly after establishing themselves as a legitimate NFC contender in 2025. Chicago returns much of the core that helped it finish 11-6 and win the NFC North last season, while Caleb Williams enters Year 3 with another season in NFL Coach of the Year odds candidate Ben Johnson’s offensive system.
The Bears were dominant in Week 1 against the Carolina Panthers and should have enough balance on both sides of the ball to control this matchup, and their ability to create pressure could make life difficult for Minnesota. For our NFL picks, Chicago offers a combination of continuity, coaching and quarterback upside that makes the Bears a sensible choice on the road.
Washington Commanders vs 
Dallas Cowboys
The Cowboys are our pick against the Giants in a divisional matchup that should give Dallas an opportunity to establish momentum early. Dak Prescott remains the centerpiece of the offense and has the experience to exploit a Giants defense that could struggle to consistently contain Dallas’ passing game.
There is also plenty of optimism surrounding the Cowboys entering 2026, even if they suffered a disappointing Week 1 loss to the Giants. Prescott’s individual performance will be worth watching throughout the season, particularly as the NFL MVP odds market develops. With Dallas favored by many preseason projections, we’re backing the Cowboys to record a Week 2 win.
Kansas City Chiefs vs 
Indianapolis Colts
The Chiefs present one of the more intriguing Week 2 picks because Patrick Mahomes is returning from the ACL injury that ended his 2025 season. Mahomes did not play during the preseason, but he played in Kansas City’s opener and should have another week to settle back into game action by Week 2. His return is also one of the biggest storylines in the NFL Comeback Player of the Year odds, making every performance especially relevant to his award case.
With Mahomes leading the offense and Arrowhead Stadium providing a major home-field advantage, we’re backing Kansas City against Indianapolis.
Our NFL Pick’Em Season Record
Just over .500 is a solid performance for an NFL team trying to make the playoffs, but it’s underwhelming for NFL pick’em pools. While we hit a few toss-ups (the Jets and Seahawks to name a few), we incorrectly backed the Dolphins, Cowboys, and Packers. It was a wild opening week, so we’ll look to improve upon things moving forward.
Using Our NFL Week 2 Pick’Em Predictions
Our NFL pick’em Week 2 predictions can be used in several different ways depending on how you participate. The most obvious option is using them as a reference when filling out an office, family or friends’ pool, especially if you’re looking for NFL pick’em help before submitting your card. They can also provide a starting point for fans who want to compare their selections with another set of opinions before kickoff.
Bettors can use the same analysis alongside current NFL pick’em odds when researching potential wagers at the top sportsbooks. If you’re new to wagering, researching how to bet on NFL games can help you understand moneylines, spreads and totals before placing a bet. You can also compare available best sportsbook promos before deciding where to wager. Remember that Pick’Em selections and betting predictions are opinions, not guarantees.
Check out our other NFL betting tools and resources
Our best NFL betting sites
To make sure you get the most value on your NFL odds, go to the best NFL betting sites prior to placing your wagers throughout the season.
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Place your first bet with the token applied. If your first bet loses, you'll get up to $1,500 back in Bonus Bets. Add’l terms apply. Must be 21+ and located in U.S. Gambling Problem? Call 1-800-GAMBLER. BetMGM Sportsbook available in AZ, CO, DC, IA, IL, IN, KS, KY, LA, MA, MD, MI, MS, NJ, NY, NC, PA, PR, OH, TN, VA, WV, WY only.
❓ NFL Week 2 Pick’Em FAQs
What is NFL Pick’Em?
NFL Pick’Em is a contest format where participants select which team they think will win each game. Depending on the pool, points may be awarded for every correct selection. It is a simple way to follow the entire NFL slate and compete against friends, family or coworkers.
How do I make NFL Pick’Em selections?
Start by reviewing every Week 2 matchup and identifying which team you believe has the best chance of winning. Consider factors such as quarterback play, injuries, home-field advantage, recent form and the matchup itself. Comparing your choices with NFL Pick’Em Week 2 analysis can also help when you’re uncertain.
Where can I get NFL Pick’Em help?
You can use expert analysis, team information, matchup statistics and available market data to help make your selections. Our NFL Pick’Em Week 2 guide provides picks and reasoning for several of the most interesting games. It can serve as a reference before you finalize your pool card.
Are NFL Pick’Em odds the same as betting odds?
Not necessarily. Pick’Em contests generally ask you to select a winner, while betting markets can include moneylines, point spreads and totals. However, NFL pick’em odds and sportsbook lines can provide useful context about which teams are favored heading into a matchup.
Can I use NFL Pick’Em predictions for betting?
You can use NFL Pick’Em Week 2 predictions as one source of information when researching bets, but they should not be treated as guaranteed outcomes. Bettors should compare the predictions with current lines, injury news and available markets. If you decide to wager, only bet what you can afford to lose.
