NFL Pick’Em Week 4: Pool Predictions for Every Game

NFL Pick’Em Week 4 gives football fans another opportunity to put their knowledge to the test as the 2026 regular season continues. Whether you’re competing in a workplace pool, playing with friends, or simply making your own selections, picking every matchup can be a challenge.

Our NFL picks break down the Week 4 slate and highlight the teams we expect to come out on top. These selections are designed to provide a starting point for anyone looking for NFL Pick’Em Week 4 guidance before making their choices. Along with our selections, we’ll examine several intriguing matchups and explain the reasoning behind our picks. Use this guide for NFL Pick’Em Week 4 preparation.

NFL Week 4 Pick’Em Selections

Making all of your selections before kickoff can be difficult, particularly when several games appear evenly matched. Our NFL Pick’Em Week 4 selections provide a straightforward starting point for pools and contests.

Download or print our free printable NFL Week 4 pick’em sheet and make your choices before the games begin.

NFL Pick’Em Week 4 Insights

Several Week 4 matchups stand out as particularly interesting when making NFL Pick’Em Week 4 selections. While some games feature clear favorites, others could come down to a handful of key plays. Here are three matchups worth paying especially close attention to when making your NFL pick’em predictions.

Cleveland Browns vs Pittsburgh Steelers

The Steelers have a strong case to beat the Browns in Week 4 despite Cleveland entering Thursday Night Football at 2-1. Pittsburgh is averaging 303.3 yards per game, while Cleveland ranks 30th at 266, giving the Steelers an opportunity to control the game with their offense. The Steelers also have eight sacks and three interceptions through three weeks, compared with seven sacks and two interceptions for Cleveland.

Pittsburgh’s 2-1 start includes a 30-27 win over Cincinnati, while the Browns narrowly beat Carolina 21-18 last week. Cleveland has Denzel Boston, who has 195 receiving yards and two touchdowns through three games and is a candidate in the NFL Offensive Rookie of the Year odds. Still, Pittsburgh’s defense can pressure Deshaun Watson and force Cleveland into another low-scoring game.

 Philadelphia Eagles vs  Los Angeles Rams

The Rams have a strong case to beat the Eagles in Week 4, especially after averaging 390 total yards per game through two weeks compared with Philadelphia’s 346. Los Angeles is also allowing just 16.5 points per game, while the Eagles are giving up 21.

The Rams’ offense has been efficient through the air and on the ground, with Matthew Stafford throwing for 482 yards and four touchdowns and Kyren Williams adding 126 rushing yards. Los Angeles is priced as a slight favorite and still has shorter Super Bowl odds despite being 1-2 through three games. That gap reflects the Rams’ strong preseason expectations and gives added context to this Week 4 matchup.

 Carolina Panthers vs  Detroit Lions

The Panthers are a legitimate Week 4 upset candidate despite losing 21-18 at Cleveland. Carolina is averaging 29.7 points and 392.7 yards per game, ranking sixth in the NFL in yards, while Detroit is allowing 31.3 points per game through three weeks. The Lions have also surrendered 368.3 yards per game, suggesting Carolina’s offense can create enough opportunities to stay competitive.

Detroit’s defense has recorded 12 sacks, but it has been less dominant overall than expected, particularly against the pass and run. Carolina’s offense has shown enough explosiveness to exploit those weaknesses, especially with Bryce Young distributing the ball. Detroit still has Jahmyr Gibbs, a leading candidate in the NFL Offensive Player of the Year odds, but Carolina can win if it keeps Gibbs contained and turns this into a high-scoring game.

Our NFL Pick’Em Season Record

We’re hovering over .500 through the first three weeks, highlighted by a strong 10-6 record in Week 3. It was a solid bounce back week for our Week 3 predictions with a few notable upsets picked correctly, including the Falcons over the Packers, Broncos over the Rams, Jaguars over the Patriots, and Bears over the Eagles on Monday Night Football.

• Week 1: 9-7
• Week 2: 8-8
• Week 3: 10-6

Overall NFL pick’em predictions record: 27-21

Using Our NFL Week 4 Pick’Em Predictions

Our NFL pick’em Week 4 predictions can be used in several different ways depending on how you participate. The most obvious option is using them as a reference when filling out an office, family or friends’ pool, especially if you’re looking for NFL pick’em help before submitting your card. They can also provide a starting point for fans who want to compare their selections with another set of opinions before kickoff.

Bettors can use the same analysis alongside current NFL pick’em odds when researching potential wagers at the top sportsbooks. If you’re new to wagering, researching how to bet on NFL games can help you understand moneylines, spreads and totals before placing a bet. You can also compare available best sportsbook promos before deciding where to wager. Remember that Pick’Em selections and betting predictions are opinions, not guarantees.

Check out our other NFL betting tools and resources

Our best NFL betting sites

To make sure you get the most value on your NFL odds, go to the best NFL betting sites prior to placing your wagers throughout the season.

❓ NFL Week 4 Pick’Em FAQs

What is NFL Pick’Em?

NFL Pick’Em is a contest format where participants select which team they think will win each game. Depending on the pool, points may be awarded for every correct selection. It is a simple way to follow the entire NFL slate and compete against friends, family or coworkers.

How do I make NFL Pick’Em selections?

Start by reviewing every Week 4 matchup and identifying which team you believe has the best chance of winning. Consider factors such as quarterback play, injuries, home-field advantage, recent form and the matchup itself. Comparing your choices with NFL Pick’Em Week 4 analysis can also help when you’re uncertain.

Where can I get NFL Pick’Em help?

You can use expert analysis, team information, matchup statistics and available market data to help make your selections. Our NFL Pick’Em Week 4 guide provides picks and reasoning for several of the most interesting games. It can serve as a reference before you finalize your pool card.

Are NFL Pick’Em odds the same as betting odds?

Not necessarily. Pick’Em contests generally ask you to select a winner, while betting markets can include moneylines, point spreads and totals. However, NFL pick’em odds and sportsbook lines can provide useful context about which teams are favored heading into a matchup.

Can I use NFL Pick’Em predictions for betting?

You can use NFL Pick’Em Week 4 predictions as one source of information when researching bets, but they should not be treated as guaranteed outcomes. Bettors should compare the predictions with current lines, injury news and available markets. If you decide to wager, only bet what you can afford to lose.