NFL Pick’Em Week 5 gives football fans another opportunity to put their knowledge to the test as the 2026 regular season continues. Whether you’re competing in a workplace pool, playing with friends, or simply making your own selections, picking every matchup can be a challenge.
Our NFL picks break down the Week 5 slate and highlight the teams we expect to come out on top. These selections are designed to provide a starting point for anyone looking for NFL Pick’Em Week 5 guidance before making their choices. Along with our selections, we’ll examine several intriguing matchups and explain the reasoning behind our picks. Use this guide for NFL Pick’Em Week 5 preparation.
NFL Week 5 Pick’Em Selections
Making all of your selections before kickoff can be difficult, particularly when several games appear evenly matched. Our NFL Pick’Em Week 5 selections provide a straightforward starting point for pools and contests.
Download or print our free printable NFL Week 5 pick’em sheet and make your choices before the games begin.
| Away |
Home |
Oddspedia Pick |
| Tampa Bay Buccaneers |
Dallas Cowboys |
Cowboys |
| Philadelphia Eagles |
Jacksonville Jaguars |
Jaguars |
| Cincinnati Bengals |
Miami Dolphins |
Bengals |
| Las Vegas Raiders |
New England Patriots |
Raiders |
| Minnesota Vikings |
New Orleans Saints |
Saints |
| Cleveland Browns |
New York Jets |
Browns |
| Houston Texans |
Tennessee Titans |
Texans |
| Indianapolis Colts |
Pittsburgh Steelers |
Colts |
| New York Giants |
Washington Commanders |
Commanders |
| Denver Broncos |
Los Angeles Chargers |
Chargers |
| Chicago Bears |
Green Bay Packers |
Packers |
| Detroit Lions |
Arizona Cardinals |
Lions |
| San Francisco 49ers |
Seattle Seahawks |
Seahawks |
| Baltimore Ravens |
Atlanta Falcons |
Ravens |
| Buffalo Bills |
Los Angeles Rams |
Rams |
NFL Pick’Em Week 5 Insights
Several Week 5 matchups stand out as particularly interesting when making NFL Pick’Em Week 5 selections. While some games feature clear favorites, others could come down to a handful of key plays. Here are three matchups worth paying especially close attention to when making your NFL pick’em predictions.
Dallas Cowboys vs 
Tampa Bay Buccaneers
The Dallas Cowboys get the nod at home against a winless Buccaneers team that has struggled to find its footing. Tampa Bay enters Week 5 at 0-3, while Dallas is 1-2 despite scoring 88 points through its first three games. The Cowboys have also won 14 of 20 all-time meetings with Tampa Bay, including a 26-24 victory in their most recent regular-season matchup in December 2024.
Todd Bowles is increasingly prominent in the next NFL coach fired odds conversation after Tampa Bay’s slow start, while Brian Schottenheimer could also face pressure if Dallas fails to turn things around. With Baker Mayfield dealing with a thumb injury, back Dallas to get the win.
Green Bay Packers vs 
Chicago Bears
The Packers have a difficult divisional matchup against a Bears team that has made an impressive start to the 2026 season. Chicago is 2-1 and averaging 29.7 points per game, compared to Green Bay’s 1-2 record and 18.7 points per game. However, the Packers have home-field advantage and plenty of familiarity with this rivalry. Chicago won the two teams’ December 2025 regular-season rematch and their January playoff meeting, making this an opportunity for Green Bay to respond.
Keep an eye on rookie Zavion Thomas, who ran a 4.28-second 40-yard dash and features among the fastest players in the NFL conversation. It will be interesting to see whether the Bears give him meaningful opportunities on offense or special teams.
Seattle Seahawks vs 
Sen Francisco 49ers
The Seahawks get the edge at home in what should be one of Week 5’s most competitive NFC matchups. San Francisco enters at 3-0, with Brock Purdy completing 72.3% of his passes for 789 yards, nine touchdowns and one interception. His early performances have pushed him into the NFL MVP odds conversation, but Seattle has already demonstrated it can compete with the NFC’s best.
The Seahawks defeated San Francisco 41-6 in last season’s divisional playoff matchup and also won their January regular-season meeting 13-3. Both teams remain prominent in the Super Bowl odds market, with Seattle and San Francisco listed at +1000 and +900, respectively. Back the defending champions to protect their home field.
Our NFL Pick’Em Season Record
We’re hovering over .500 through the first three weeks, highlighted by another strong performance in Week 4. We hit big with a few notable upsets in our Week 4 predictions, including the Jaguars over the Bengals, Panthers over the Lions, and Cowboys over the Texans.
- Week 1: 9-7
- Week 2: 8-8
- Week 3: 10-6
- Week 4: 10-6
Overall NFL pick’em predictions record: 37-27
Using Our NFL Week 5 Pick’Em Predictions
Our NFL pick’em Week 5 predictions can be used in several different ways depending on how you participate. The most obvious option is using them as a reference when filling out an office, family or friends’ pool, especially if you’re looking for NFL pick’em help before submitting your card. They can also provide a starting point for fans who want to compare their selections with another set of opinions before kickoff.
Bettors can use the same analysis alongside current NFL pick’em odds when researching potential wagers at the top sportsbooks. If you’re new to wagering, researching how to bet on NFL games can help you understand moneylines, spreads and totals before placing a bet. You can also compare available best sportsbook promos before deciding where to wager. Remember that Pick’Em selections and betting predictions are opinions, not guarantees.
Check out our other NFL betting tools and resources
Our best NFL betting sites
To make sure you get the most value on your NFL odds, go to the best NFL betting sites prior to placing your wagers throughout the season.
5
$1,500 First Bet Offer
Claim bonus
Place your first bet with the token applied. If your first bet loses, you'll get up to $1,500 back in Bonus Bets. Add’l terms apply. Must be 21+ and located in U.S. Gambling Problem? Call 1-800-GAMBLER. BetMGM Sportsbook available in AZ, CO, DC, IA, IL, IN, KS, KY, LA, MA, MD, MI, MS, NJ, NY, NC, PA, PR, OH, TN, VA, WV, WY only.
❓ NFL Week 5 Pick’Em FAQs
What is NFL Pick’Em?
NFL Pick’Em is a contest format where participants select which team they think will win each game. Depending on the pool, points may be awarded for every correct selection. It is a simple way to follow the entire NFL slate and compete against friends, family or coworkers.
How do I make NFL Pick’Em selections?
Start by reviewing every Week 5 matchup and identifying which team you believe has the best chance of winning. Consider factors such as quarterback play, injuries, home-field advantage, recent form and the matchup itself. Comparing your choices with NFL Pick’Em Week 5 analysis can also help when you’re uncertain.
Where can I get NFL Pick’Em help?
You can use expert analysis, team information, matchup statistics and available market data to help make your selections. Our NFL Pick’Em Week 5 guide provides picks and reasoning for several of the most interesting games. It can serve as a reference before you finalize your pool card.
Are NFL Pick’Em odds the same as betting odds?
Not necessarily. Pick’Em contests generally ask you to select a winner, while betting markets can include moneylines, point spreads and totals. However, NFL pick’em odds and sportsbook lines can provide useful context about which teams are favored heading into a matchup.
Can I use NFL Pick’Em predictions for betting?
You can use NFL Pick’Em Week 5 predictions as one source of information when researching bets, but they should not be treated as guaranteed outcomes. Bettors should compare the predictions with current lines, injury news and available markets. If you decide to wager, only bet what you can afford to lose.
